Abstract
A rapid and sensitive analytical method was developed for the spectrophotometry assay of prazosin hydrochloride. The method is based on the formation of a coloured derivative between the drug and 1,2naphthoquinone-4-sulfonic acid sodium salt (NQS). The reaction proceeds quantitatively at pH = 4.5 and 70 C in 40 min. After the extraction of the derivative with chloroform: n-butanol (3:1), the absorbance was measured at 400 nm. The method was applied to commercially available tablets and the results were statistically compared with those obtained by an ultraviolet spectrophotometry and differential pulse polarographic methods using t-and F-tests.
Keywords
Chemistry
Chromatography
Prazosin
Reagent
Hydrochloride
Quinazoline
Dosage form
High-performance liquid chromatography
Combinatorial chemistry
Organic chemistry
Antagonist
Subject Areas
Analytical Methods in Pharmaceuticals
·Analytical Chemistry ·Physical Sciences
Analytical Chemistry and Chromatography
·Spectroscopy ·Physical Sciences
Analytical Chemistry and Sensors
·Bioengineering ·Physical Sciences
Citations by Year
2012: 1
2015: 2
2016: 1
2020: 1
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