Journal Article

·2024

Condensation of Amines with S-Methyl Thiouronium Salts: Another Entry for the Synthesis of Amidines

Toreshettahally R. Swaroop YTU , Lokman Torun YTU , Rahym Bakyyev YTU , Kanchugarakoppal S. Rangappa

Synlett

Abstract

Abstract We present a condensation of primary aryl or alkyl amines with S-methyl thiouronium salts to obtain N,N,N′-trisubstituted amidines. High yields, short reaction times, and a fair substrate scope are the noteworthy features of this protocol. Surprisingly, the reaction of a thiouronium salt with 4-aminopyridine gave 1-(4-methoxybenzoyl)piperidine.

Keywords

Chemistry Salt (chemistry) Piperidine Condensation Alkyl Aryl Substrate (aquarium) Primary (astronomy) Medicinal chemistry Organic chemistry Combinatorial chemistry

Subject Areas

Quinazolinone synthesis and applications ·Organic Chemistry ·Physical Sciences
Synthesis of heterocyclic compounds ·Organic Chemistry ·Physical Sciences
Synthesis and Catalytic Reactions ·Organic Chemistry ·Physical Sciences

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