Determination of Trace Element Concentrations in Blood Samples and Their Correlation to Breast Cancer

Abstract

The main purpose of this study was to investigate the possible differences in the concentrations of Al, Cu, Ca, Mg, Fe, Ni, and Pb in breast cancer patients and healthy control group. One blood sample each was collected from 40 adult female patients diagnosed with breast cancer and 40 healthy adult female individuals with no medical history of cancer. The concentrations of the elements Al, Cu, Fe, Ni, and Pb were determined by ICP-MS, while Ca and Mg were determined by ICP-OES. Statistical analysis was performed with the Kolmogorov-Smirnov normality test, the Mann-Whitney U test, and the Spearman's rank correlation test. It was observed that the concentrations of Cu and Mg in the breast cancer patients were significantly higher (p=0.000