Development of an Experimental Home Bleaching Agent Containing Chitosan Nanoparticles Loaded with Gypsophila arrostii Extract

Abstract

Objectives: Peroxide alternative agents are currently being developed to provide a safe and effective tooth whitening treatment, given the potential for these agents to affect hard dental tissue. In this study, it is aimed to produce an experimental home whitening gel containing Gypsophila arrostii extract (GE) loaded chitosan nanoparticles with controlled release property. Materials and Methods: GE was prepared in two different ways using water or ethanol, and the saponin amounts of both extracts were measured using gravimetric analysis methods. GE-loaded chitosan nanoparticles (GECNPs) prepared by the ionic gelation method were investigated in terms of size, zeta potential, polydispersity index (PdI), encapsulation efficiency, and release profile. The significance level was set at p