Abstract
Metabolic diseases are major global health problems caused by genetic predisposition and nutritional factors. Advances in nutrigenomics have enabled the development of nutritional strategies by revealing the effects of nutrients on gene expression. This review mentions different investigations related to the role of nutrient-gene interactions in metabolic diseases including obesity, diabetes, cancer, and non-alcoholic fatty liver disease. The findings showed that secondary metabolites, macronutrients, and micronutrients can influence diseases by regulating gene expressions. Understanding the complex interactions between nutrients and genes will contribute to developing disease prevention and treatment strategies with fewer or no side effects.