Abstract
In this paper, we investigate dynamics of voltage-gated ionic channels which are of great importance in integrating the information received by neurons. Understanding of dynamical behavior of voltage-gated ionic channels plays a major role for determining underlying mechanism of spike activity and predicting the neuronal behavior. Investigation is carried out based on Hodgkin-Huxley (H-H) mathematical formalism. Ionic channel gate model is discussed briefly. Relaxation phenomenon is studied in the gate variables. Then effects of temperature on dynamics of gate variables are examined. Finally voltage-clamped simulations are carried out to determine their dynamic behaviors based on squid giant axon.
Keywords
Ionic bonding
Function (biology)
Voltage
Voltage-gated ion channel
Chemistry
Ion channel
Ion
Electrical engineering
Engineering
Biology
Cell biology
Subject Areas
Ion channel regulation and function
·Molecular Biology ·Life Sciences
Neural dynamics and brain function
·Cognitive Neuroscience ·Life Sciences
Neuroscience and Neural Engineering
·Cellular and Molecular Neuroscience ·Life Sciences
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