Abstract
This study aims to prepare sodium alginate/gelatin-based delivery systems for paracetamol (C₈H₉NO₂) and metformin HCl (C₄H₁₁N₅·HCl). Twelve sodium alginate/gelatin-based hydrogel films were synthesized using the casting method with the addition of hydroxyapatite, starch, and clinoptilolite. The drug release properties of the hydrogels were investigated in a pH 7.4 medium. Based on drug release performance, model hydrogels containing paracetamol and metformin HCl were selected. The selected hydrogels were characterized using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscope (SEM). It was determined that the selected hydrogels are suitable delivery systems for the active pharmaceutical ingredients.
Keywords
Metformin
Transdermal
In vitro
Self-healing hydrogels
Drug
Pharmacology
Chemistry
Medicine
Subject Areas
Advancements in Transdermal Drug Delivery
·Pharmaceutical Science ·Life Sciences
Hydrogels: synthesis, properties, applications
·Molecular Medicine ·Life Sciences
Drug Solubulity and Delivery Systems
·Pharmaceutical Science ·Life Sciences