Abstract
Abstract Treatment of 2,3,5,6‐tetraphenylpyrazine ( 1 ) with sodium in tetrahydrofuran effected the formation of monomeric dianion 2 . The chemical behaviour of this new disodium adduct was characterized by a variety of reagents. Generally, the protonation (water), alkylation (methyl iodide and benzyl chloride), and acylation (methyl and ethyl chloroformate) products were 1,2‐dihydrotetraphenyldiazine derivatives. An annulation of the pyrazine ring system was accomplished by treating the dianion with polymethylene chlorides, Cl(CH 2 ) n Cl, n = 2, 3, 4.
Keywords
Chemistry
Pyrazine
Diazine
Ethyl chloroformate
Methyl iodide
Alkylation
Medicinal chemistry
Adduct
Tetrahydrofuran
Alkali metal
Annulation
Acylation
Protonation
Benzoyl chloride
Organic chemistry
Chloride
Reagent
Catalysis
Subject Areas
Synthesis and Biological Evaluation
·Organic Chemistry ·Physical Sciences
Chemical Synthesis and Analysis
·Molecular Biology ·Life Sciences
Oxidative Organic Chemistry Reactions
·Organic Chemistry ·Physical Sciences
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