Abstract
Crackles and their time-domain characteristics provide important clues about different lung diseases. In this paper, we aim to de-noise synthetically produced crackles under various noise levels while preserving their information bearing parts which significantly affect crackle parameters. Classical wavelet based de-noising algorithms are deteriorated by sharp-sudden noise changes and produce Gibbs like fluctuations. On the other hand, total variation based algorithms, which are capable of alleviating the drawbacks of the classical wavelet based algorithms, are failed when dealing with piecewise-smooth signals like crackles and generate unwanted flat regions on the de-noised signals. Proposed wavelet total variation based de-noising is succeed in removing undesired artefacts originating from both classical wavelet and total variation de-noising. The proposed method is compared with classical wavelet based de-noising methods in terms of root mean square error under various white Gaussian noise levels (0 - 20 dB SNR). Moreover, in order to emphasize the de-noising ability of the methods, without deforming crackle waveform, time and frequency domain representation of a noisy and de-noised crackle is validated visually.