Journal Article

·2017 OPEN ACCESS

Polymorphisms and Protein Expressions of Glutathione S-Transferase M1 and T1 in Non-Small Cell Lung Cancer

Murat Kılıç , Ahmet O. Ada , Serpil Oğuztüzün , Funda Demirağ , Sezgin Çeli̇k YTU , Pınar Bıçakçıoğlu YTU , Mümtaz İŞCAN

Turkish Journal of Pharmaceutical Sciences

Abstract

OBJECTIVES: in lung tissues of patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: For protein expression and gene deletion studies, tumor and surrounding tumor free (normal) tissue of 33 patients with NSCLC were used. In paraffin-embedded tissues, immunohistochemistry was used to detect protein expressions, and multiplex polymerase chain reaction amplification was used to identify gene deletions. RESULTS: genes (p=0.001). CONCLUSION: protein expression is higher in tumors compared with normal lung tissues of patients with NSCLC.

Keywords

Gene Immunohistochemistry Glutathione S-transferase Lung cancer Biology Molecular biology Cancer research Gene expression Glutathione Pathology Genetics Medicine Immunology Enzyme Biochemistry

Subject Areas

Glutathione Transferases and Polymorphisms ·Molecular Biology ·Life Sciences
Genomics, phytochemicals, and oxidative stress ·Molecular Biology ·Life Sciences
Epigenetics and DNA Methylation ·Molecular Biology ·Life Sciences

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