Preparation of Hybrid Films Containing Chitosan, Starch, Ascorbic Acid, and Different Metal Ions for Release of Doxorubicin

Abstract

As known, composite films containing different metal ions provide improvement in the properties of drug release systems. In this study, it was aimed to prepare composite films containing different metal ions for DOX release, and the effect of metal ions on drug release, swelling, and thermal properties were investigated. The structural characterization of the composite films was carried out using FT-IR, SEM, and TG analysis techniques. SEM images showed that the metal-free film was composed of a homogeneous structure while the calcium composite films consisted of a non-homogenous surface. Also, thermal analysis results showed that the thermal stability increased with the addition of metal ions to the composite film matrix. The swelling and drug-release behavior of the composite films were also studied, and metal ions-containing films exhibited a higher swelling performance and drug-release behavior than the metal-free composite.