Preparation of Photopolymerizable HEMA/PEG-DA Based Hydrogels Filled with Low Concentrations of Nanoparticle Titanium Dioxide for Release Of Donepezil HCl

Abstract

: 2-hydroxyl ethyl methacrylate/poly(ethylene glycol) diacrylate (HEMA/PEG-DA) based hydrogels are attractive drug carriers due to their appealing properties such as biodegradability and sustained release. The scope of this study was to investigate the swelling and release behaviors of HEMA/PEG-DA-based hydrogels filled with low concentrations of nanoparticle titanium dioxide (TiO2). Hydrogels have been synthesized successfully by photopolymerization. 2,2-Dimethoxy-2-Phenyl-Acetophenone (Irgacure 651), 1-Hydroxycyclohexyl Phenyl Ketone (Irgacure 184) and 2-Hydroxy-4'-(2-Hydroxyethoxy)-2 Methylpropiophenone (Irgacure 2959) were selected for photopolymerization. Fourier Transform Infrared Spectroscopy (FT-IR) had been used in confirming the functional group of hydrogels. A digital microscope and Scanning Electron Microscope (SEM) were used for characterizing synthesized hydrogels. This study revealed that the content of hydrogels, the kind of photo-initiators and pH have a significant effect on the swelling and releasing of Donepezil Hydrochloride (active pharmaceutical ingredient (API) for Alzheimer disease) behaviours.