Abstract
Abstract The reductive metallation of 6‐methyl‐2,3‐diphenylquinoxaline 1 with sodium metal in tetrahydrofuran and inert atmosphere to a monomeric dianion 2 has been explored and the nucleophilicity of this disodium adduct was investigated with various alkylation and acylation reagents. An annulation of the pyrazine ring system was accomplished by treating the dianion with polymethylene chlorides, Cl(CH 2 ) n Cl, n = 3,4.
Keywords
Chemistry
Pyrazine
Annulation
Tetrahydrofuran
Diazine
Reagent
Alkylation
Adduct
Medicinal chemistry
Ring (chemistry)
Nucleophile
Organic chemistry
Catalysis
Subject Areas
Synthesis and Biological Evaluation
·Organic Chemistry ·Physical Sciences
Chemical Synthesis and Analysis
·Molecular Biology ·Life Sciences
Coordination Chemistry and Organometallics
·Organic Chemistry ·Physical Sciences
Citations by Year
2018: 1
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Clean water and sanitation 70%
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