Preprint

·2024 OPEN ACCESS

Revealing Distinctive Insights: Machine Learning-Enhanced Ensembled MRI Sequences for Pediatric Posterior Fossa Tumor Classification

Serhat Ünalan YTU , Fatih Ekrem Onat YTU , Feyza Şahin YTU , Bilgin Keserci YTU

Research Square

Abstract

Pediatric posterior fossa (PF) tumors pose a significant concern in pediatric oncology because of their high prevalence in the pediatric population. Magnetic Resonance Imaging (MRI) has emerged as a practical and non-invasive imaging modality for detecting and classifying PF malignancies. For the differentiation of MB, the LGBM model, using the feature combination of T2, FLAIR, DWI, and ADC, demonstrated the highest performance. It achieved an AUROC of 0.938, accuracy of 0.778, specificity of 0.916, sensitivity of 0.645, and F1 score of 0.664. In the classification of EP, the XGB model, which utilizes the feature combination of T2 and DWI, demonstrated the highest performance with a sensitivity of 1. With respect to the distinction of PA, the RF model, using the feature combination of T2, T1CE, DWI, and ADC, exhibited the highest performance. For the classification of BG, the RF model, using the feature combination of T2, DWI, and ADC, exhibited the highest performance. This comprehensive approach has notably enhanced our comprehension of pediatric PF tumor classification and carries substantial potential for the advancement of diagnostic tools and the refinement of ML models.

Keywords

Posterior fossa Artificial intelligence Computer science Anatomy Medicine

Subject Areas

Radiomics and Machine Learning in Medical Imaging ·Radiology, Nuclear Medicine and Imaging ·Health Sciences
Brain Tumor Detection and Classification ·Neurology ·Life Sciences
Fetal and Pediatric Neurological Disorders ·Pediatrics, Perinatology and Child Health ·Health Sciences

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