Journal Article

·2013

Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity†

Irem Kulu YTU , Asli Kopruceli YTU , Gökce Göksu YTU , Nüket Öcal YTU

Current Organic Synthesis

Abstract

The C-C coupling of bicyclic alkene 4 with aryl and heteroaryl iodides gave under reductive Heck conditions the Caryl( hetaryl), N-[((4-pyrimidin-2-yl)piperazin-1-yl)butyl]substituted bicyclic imides 5a-f. The [3+2] cycloadditions of 4 with various nitrile oxides yielded the bridged isoxazoline derivatives 6-8 with potential biological activity. Keywords: Antidepressant drugs, bicyclic imides, biological activity, C-C coupling, isoxazolines, palladium(II) acetate, arylpiperazine moiety.

Keywords

Chemistry Bicyclic molecule Heck reaction Moiety Aryl Nitrile Alkene Cycloaddition Organic chemistry Palladium 1,3-Dipolar cycloaddition Stereochemistry Medicinal chemistry Combinatorial chemistry Catalysis Alkyl

Subject Areas

Organic Chemistry Cycloaddition Reactions ·Organic Chemistry ·Physical Sciences
Synthesis and Reactions of Organic Compounds ·Organic Chemistry ·Physical Sciences
Synthesis and Biological Evaluation ·Organic Chemistry ·Physical Sciences

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