Abstract
New tandospirone analogues containing a 1-[3-(trifluoromethyl)phenyl]piperazine (TFMPP) moiety have been synthesized by hydroarylation reactions with Pd(OAc)2. The perhydroisoindole derivatives were obtained by the reaction of reduced starting material with aryl-(heteroaryl) iodides under the same conditions. Spiro-1,3-indandionolylpyrrolidine derivatives having an array of stereocenters are reported.
Keywords
Chemistry
Trifluoromethyl
Piperazine
Stereocenter
Moiety
Aryl
Stereochemistry
Medicinal chemistry
Reaction conditions
Organic chemistry
Catalysis
Alkyl
Enantioselective synthesis
Subject Areas
Fluorine in Organic Chemistry
·Pharmaceutical Science ·Life Sciences
Synthetic Organic Chemistry Methods
·Organic Chemistry ·Physical Sciences
Coordination Chemistry and Organometallics
·Organic Chemistry ·Physical Sciences
Citations by Year
2017: 1
2020: 1
2024: 2
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