Synthesis of Palladium Phthalocyanine and Investigation of Sono-Photodynamic Therapy Properties

Abstract

In this study, it is desired to apply Sono-photodynamic Therapy (SPDT) method to create a more effective therapeutic outcome. For this purpose, a new palladium phthalocyanine (PdPc) (2) was synthesized and characterized by standard spectroscopy methods. Then it's photochemical and photophysical properties were determined in DMSO. Singlet oxygen quantum yield of the complex (2) was calculated by both PDT and SPDT method. The SPDT method (∆ =0.90) was found to be more effective than the PDT method (∆ =0.74), to obtain high singlet oxygen quantum yield. All the results show that, SPDT improves the therapeutic effects and the new PdPc can be a potential photosensitizer in PDT / or SPDT.