Abstract
were determined by RT-PCR as developmental indicators. MTS and RT-cell analysis showed increased cell viability by NSA, whereas SSA decreased cell viability. NSA beneficially affected zebrafish embryo development while SSA exerted deleterious effects through oxidant-antioxidant status, inflammation, and development. Results of our study showed for the first time that synthesis of salicylic acid from wintergreen oil by green chemistry overcomes its cytotoxicity in keratinocyte cells and teratogenicity in zebrafish embryos. This finding is important for drug research on safe topical applications during pregnancy, when preventing exposure to drug and chemical-derived teratogens is vital.
Keywords
Salicylic acid
HaCaT
Chemistry
Viability assay
Catalase
Biochemistry
Keratinocyte
Cytotoxicity
Lipid peroxidation
Antioxidant
Pharmacology
Biology
Cell
In vitro
Subject Areas
Pregnancy and Medication Impact
·Public Health, Environmental and Occupational Health ·Health Sciences
Reproductive System and Pregnancy
·Immunology ·Life Sciences
Estrogen and related hormone effects
·Genetics ·Life Sciences
Citations by Year
2024: 2
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