Abstract
KNOTTED1 (KN1)-like homeobox (KNOX) transcription factors function in plant meristems, self-renewing structures consisting of stem cells and their immediate daughters. We defined the KN1 cistrome in maize inflorescences and found that KN1 binds to several thousand loci, including 643 genes that are modulated in one or multiple tissues. These KN1 direct targets are strongly enriched for transcription factors (including other homeobox genes) and genes participating in hormonal pathways, most significantly auxin, demonstrating that KN1 plays a key role in orchestrating the upper levels of a hierarchical gene regulatory network that impacts plant meristem identity and function.
Keywords
Homeobox
Biology
Meristem
Homeobox A1
Transcription factor
HNF1B
Gene
Genetics
Homeobox protein Nkx-2.5
Auxin
Transcription (linguistics)
Cell biology
Homeotic gene
Computational biology
Subject Areas
Plant Molecular Biology Research
·Plant Science ·Life Sciences
Plant Reproductive Biology
·Molecular Biology ·Life Sciences
Plant Gene Expression Analysis
·Molecular Biology ·Life Sciences
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