Abstract

This work presents synthesis and characterization of the some pyridyl-substituted Schiff bases and their labeling with Tc-99m. The eleven heterocyclic Schiff bases have been synthesized from the condensation reactions of pyridine-2-aldehyde with derivative of aminophenol, aniline and aminopyridine compounds. Structure of all synthesized compounds have been determined by using the data obtained from their ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) and mass (MS) spectral results. Schiff base derivatives of pyridine-2-aldehyde were labeled with Tc-99m and their radiochemical purity was calculated by using chromatographic methods (TLC and HPLC); and obtained chromatograms have been evaluated by TLC scintigraphy system and gamma counters.